NSAID Copper(II) Complexes

Non-steroid anti-inflammatory drugs or NSAIDs are a group of drugs used to reduce pain, prevent blood clots, decrease fevers, and decrease inflammation. Many of these drugs can act as ligands with copper(II) ions to form complexes. Coordination bonds form between the copper and the oxygen in the carboxylate groups in the NSAID compounds. The copper(II) complexes formed with NSAIDs are being researched due to their increased effectiveness as anti-inflammatories. In addition, these complexes may not present many of the issues that the base drugs cause like kidney problems and ulceration in the gastrointestinal track.

NSAID Copper Complexes
Copper(II) Aspirinate

Copper(II) Ibuprofenate

Copper(II) Naproxenate

Copper(II) Diclfenac

Copper(II) Mefenamic

Copper(II) Flufenamato

Copper(II) Diflunnisal

Copper(II) Tolfenamato

Copper(II) Oxaprozin

Copper(II) Niflumato

Copper(II) Mefenamato

Synthesis
Copper(II) NSAIDs can be made by reacting them with sodium carbonate to create a sodium NSAID, water, and carbon dioxide. Sodium hydroxide cannot be used as it can hydrolyze certain NSAIDs like aspirin.

The sodium NSAID can then be reacted with copper(II) sulfate in aqueous solution to form the Cu(II) NSAID comp

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