Copper(II) Ibuprofenate

Copper(II) ibuprofenate is an chemical complex of copper(II) and ibuprofen, which has the chemical formula Cu 2 (C 13 H 17 O 2 ) 4. It can either be found as a dihydrate or anhydrous. Copper(II) ibuprofenate, like many other copper(II) complexes of NSAIDs (nonsteroidal anti-inflammatory drugs), could be a more effective anti-inflammatory and may not have the same adverse effects the base drug present.

Synthesis
One method to create copper(II) ibuprofenate involes first creating sodium ibuprofenate by reaction of ibuprofen with sodium carbonate or sodium bicaronate at 60 °C in water. Ibuprofen has a low solubility in water, but sodium asprirnate has a high solubility, which allows it to dissolve easily.

Sodium ibuprofenate can then be mixed with a solution of copper(II) sulfate to create the copper(II) ibuprofenate.

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